Package: segregatr
Title: Segregation Analysis for Variant Interpretation
Version: 0.5.0
Authors@R: c(
    person("Magnus Dehli", "Vigeland", , "m.d.vigeland@medisin.uio.no", role = c("aut", "cre"),
           comment = c(ORCID = "0000-0002-9134-4962")),
    person("Christian", "Carrizosa", role = "aut",
           comment = c(ORCID = "0000-0002-3919-0011"))
  )
Description: An implementation of the full-likelihood Bayes factor
        (FLB) for evaluating segregation evidence in clinical medical
        genetics. The method was introduced by Thompson et al. (2003)
        <doi:10.1086/378100>. This implementation supports custom
        penetrance values and liability classes, and allows
        visualisations and robustness analysis as presented in Ratajska
        et al. (2023) <doi:10.1002/mgg3.2107>. See also the online app
        'shinyseg', <https://chrcarrizosa.shinyapps.io/shinyseg>, which
        offers interactive segregation analysis with many additional
        features (Carrizosa et al. (2024)
        <doi:10.1093/bioinformatics/btae201>).
License: GPL-3
URL: https://github.com/magnusdv/segregatr
BugReports: https://github.com/magnusdv/segregatr/issues
Depends: pedtools (>= 2.2.0), R (>= 4.1.0)
Imports: pedprobr
Suggests: testthat
Encoding: UTF-8
Language: en-GB
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.3.2
Repository: https://magnusdv.r-universe.dev
Date/Publication: 2025-08-25 17:08:42 UTC
RemoteUrl: https://github.com/magnusdv/segregatr
RemoteRef: HEAD
RemoteSha: 1674c50a3f646909966044c6647c32da6ac4c9e7
NeedsCompilation: no
Packaged: 2026-06-22 14:17:02 UTC; root
Author: Magnus Dehli Vigeland [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-9134-4962>),
  Christian Carrizosa [aut] (ORCID:
    <https://orcid.org/0000-0002-3919-0011>)
Maintainer: Magnus Dehli Vigeland <m.d.vigeland@medisin.uio.no>